We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
6loh
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Crystal structure of the catalytic domain of human ubiquitin ligase AREL1== | ==Crystal structure of the catalytic domain of human ubiquitin ligase AREL1== | ||
| - | <StructureSection load='6loh' size='340' side='right'caption='[[6loh]]' scene=''> | + | <StructureSection load='6loh' size='340' side='right'caption='[[6loh]], [[Resolution|resolution]] 3.21Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LOH OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6loh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LOH FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.207Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6loh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6loh OCA], [https://pdbe.org/6loh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6loh RCSB], [https://www.ebi.ac.uk/pdbsum/6loh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6loh ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AREL1_HUMAN AREL1_HUMAN] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation.<ref>PMID:23479728</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chen ZZ]] | [[Category: Chen ZZ]] | ||
[[Category: Li ZH]] | [[Category: Li ZH]] | ||
[[Category: Shang GH]] | [[Category: Shang GH]] | ||
Current revision
Crystal structure of the catalytic domain of human ubiquitin ligase AREL1
| |||||||||||
