7boj

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Current revision (10:48, 27 March 2024) (edit) (undo)
 
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<StructureSection load='7boj' size='340' side='right'caption='[[7boj]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='7boj' size='340' side='right'caption='[[7boj]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7boj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_mc2_155 Mycolicibacterium smegmatis mc2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BOJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7boj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BOJ FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7boj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7boj OCA], [https://pdbe.org/7boj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7boj RCSB], [https://www.ebi.ac.uk/pdbsum/7boj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7boj ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7boj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7boj OCA], [https://pdbe.org/7boj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7boj RCSB], [https://www.ebi.ac.uk/pdbsum/7boj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7boj ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A0R4H0_MYCS2 A0R4H0_MYCS2]
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Encapsulins containing dye-decolorizing peroxidase (DyP)-type peroxidases are ubiquitous among prokaryotes, protecting cells against oxidative stress. However, little is known about how they interact and function. Here, we have isolated a native cargo-packaging encapsulin from Mycobacterium smegmatis and determined its complete high-resolution structure by cryogenic electron microscopy (cryo-EM). This encapsulin comprises an icosahedral shell and a dodecameric DyP cargo. The dodecameric DyP consists of two hexamers with a twofold axis of symmetry and stretches across the interior of the encapsulin. Our results reveal that the encapsulin shell plays a role in stabilizing the dodecameric DyP. Furthermore, we have proposed a potential mechanism for removing the hydrogen peroxide based on the structural features. Our study also suggests that the DyP is the primary cargo protein of mycobacterial encapsulins and is a potential target for antituberculosis drug discovery.
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Cryo-EM structure of Mycobacterium smegmatis DyP-loaded encapsulin.,Tang Y, Mu A, Zhang Y, Zhou S, Wang W, Lai Y, Zhou X, Liu F, Yang X, Gong H, Wang Q, Rao Z Proc Natl Acad Sci U S A. 2021 Apr 20;118(16). pii: 2025658118. doi:, 10.1073/pnas.2025658118. PMID:33853951<ref>PMID:33853951</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7boj" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Mycolicibacterium smegmatis mc2 155]]
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[[Category: Mycolicibacterium smegmatis MC2 155]]
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[[Category: Gong, H R]]
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[[Category: Gong HR]]
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[[Category: Mu, A]]
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[[Category: Mu A]]
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[[Category: Rao, Z H]]
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[[Category: Rao ZH]]
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[[Category: Tang, Y T]]
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[[Category: Tang YT]]
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[[Category: Wang, Q]]
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[[Category: Wang Q]]
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[[Category: Cargo loaded]]
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[[Category: Icosahedral shell]]
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[[Category: Nanocompartment]]
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[[Category: Virus like particle]]
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Current revision

Cryo-EM structure of the encapsulin shell from Mycobacterium smegmatis

PDB ID 7boj

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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