7bvg

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Current revision (10:49, 27 March 2024) (edit) (undo)
 
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<StructureSection load='7bvg' size='340' side='right'caption='[[7bvg]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
<StructureSection load='7bvg' size='340' side='right'caption='[[7bvg]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7bvg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2] and [http://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_mc2_155 Mycolicibacterium smegmatis mc2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BVG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7BVG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7bvg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BVG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BXY:ALPHA-D-ARABINOFURANOSE'>BXY</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=F8L:[(2Z,6E,10E,14Z,18E,22Z,26Z)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl]+[(2S,3S,4S,5R)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]+hydrogen+phosphate'>F8L</scene>, <scene name='pdbligand=PNS:4-PHOSPHOPANTETHEINE'>PNS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">embA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2]), embB, MSMEI_6221 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BXY:ALPHA-D-ARABINOFURANOSE'>BXY</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=F8L:[(2Z,6E,10E,14Z,18E,22Z,26Z)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl]+[(2S,3S,4S,5R)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]+hydrogen+phosphate'>F8L</scene>, <scene name='pdbligand=PNS:4-PHOSPHOPANTETHEINE'>PNS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Indolylacetylinositol_arabinosyltransferase Indolylacetylinositol arabinosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.34 2.4.2.34] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bvg OCA], [https://pdbe.org/7bvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bvg RCSB], [https://www.ebi.ac.uk/pdbsum/7bvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bvg ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7bvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bvg OCA], [http://pdbe.org/7bvg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7bvg RCSB], [http://www.ebi.ac.uk/pdbsum/7bvg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7bvg ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACPM_MYCS2 ACPM_MYCS2]] Acyl carrier protein involved in meromycolate extension.
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[https://www.uniprot.org/uniprot/A0R613_MYCS2 A0R613_MYCS2]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The arabinosyltransferases EmbA, EmbB, and EmbC are involved in Mycobacterium tuberculosis cell wall synthesis and are recognized as the targets for the anti-tuberculosis drug ethambutol. We have determined cryo-electron microscopy and x-ray crystal structures of mycobacterial EmbA-EmbB and EmbC-EmbC complexes, in the presence of their glycosyl donor and acceptor substrates and with ethambutol. These structures show how the donor and acceptor substrates bind in the active site and how ethambutol inhibits by binding to the same site as both substrates in EmbB and EmbC. The majority of drug-resistant mutations are located nearby to the ethambutol-binding site. Collectively, our work provides a structural basis for understanding the biochemical function and inhibition of arabinosyltransferases and development of new anti-tuberculosis agents.
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Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol.,Zhang L, Zhao Y, Gao Y, Wu L, Gao R, Zhang Q, Wang Y, Wu C, Wu F, Gurcha SS, Veerapen N, Batt SM, Zhao W, Qin L, Yang X, Wang M, Zhu Y, Zhang B, Bi L, Zhang X, Yang H, Guddat LW, Xu W, Wang Q, Li J, Besra GS, Rao Z Science. 2020 Apr 23. pii: science.aba9102. doi: 10.1126/science.aba9102. PMID:32327601<ref>PMID:32327601</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7bvg" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Indolylacetylinositol arabinosyltransferase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Mycolicibacterium smegmatis mc2 155]]
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[[Category: Mycolicibacterium smegmatis MC2 155]]
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[[Category: Mycs2]]
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[[Category: Besra GS]]
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[[Category: Besra, G S]]
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[[Category: Gao Y]]
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[[Category: Gao, Y]]
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[[Category: Li J]]
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[[Category: Li, J]]
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[[Category: Rao Z]]
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[[Category: Rao, Z]]
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[[Category: Wang Q]]
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[[Category: Wang, Q]]
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[[Category: Zhang L]]
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[[Category: Zhang, L]]
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[[Category: Zhao Y]]
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[[Category: Zhao, Y]]
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[[Category: Acyl carrier protein]]
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[[Category: Arabinogalactan]]
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[[Category: Arabinosyltransferase]]
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[[Category: Cell wall synthesis]]
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[[Category: Drug resistance]]
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[[Category: Drug target]]
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[[Category: Emba]]
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[[Category: Embb]]
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[[Category: Embc]]
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[[Category: Ethambutol]]
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[[Category: Lipoarabinomannan]]
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[[Category: Mycobacterium smegmati]]
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[[Category: Transferase]]
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Current revision

Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with di-arabinose.

PDB ID 7bvg

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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