7c0q

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Current revision (10:50, 27 March 2024) (edit) (undo)
 
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<StructureSection load='7c0q' size='340' side='right'caption='[[7c0q]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='7c0q' size='340' side='right'caption='[[7c0q]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7c0q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_33152 Atcc 33152]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C0Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C0Q FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7c0q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C0Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C0Q FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lpg2505 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=446 ATCC 33152])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c0q OCA], [https://pdbe.org/7c0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c0q RCSB], [https://www.ebi.ac.uk/pdbsum/7c0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c0q ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c0q OCA], [https://pdbe.org/7c0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c0q RCSB], [https://www.ebi.ac.uk/pdbsum/7c0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c0q ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q5ZSL2_LEGPH Q5ZSL2_LEGPH]
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To create an intracellular niche permissive for its replication, Legionella pneumophila uses hundreds of effectors to target a wide variety of host proteins and manipulate specific host processes such as immune response, and vesicle trafficking. To avoid unwanted disruption of host physiology, this pathogen also imposes precise control of its virulence by the use of effectors called metaeffectors to regulate the activity of other effectors. A number of effector/metaeffector pairs with distinct regulatory mechansims have been characterized, including abrogation of protein modifications, direct modification of the effector and direct binding to the catalytic pocket of the cognate effector. Recently, MesI (Lpg2505) was found to be a metaeffector of SidI, an effector involved in inhibiting host protein translation. Here we demonstrate that MesI functions by inhibiting the activity of SidI via direct protein-protein interactions. We show that this interaction occurs within L. pneumophila and thus interferes with the translocation of SidI into host cells. We also solved the structure of MesI, which suggests that this protein does not have an active site similar to any known enzymes. Analysis of deletion mutants allowed the identification of regions within SidI and MesI that are important for their interactions.
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The metaeffector MesI regulates the activity of the Legionella effector SidI through direct protein-protein interactions.,McCloskey A, Perri K, Chen T, Han A, Luo ZQ Microbes Infect. 2021 Feb 8:104794. doi: 10.1016/j.micinf.2021.104794. PMID:33571674<ref>PMID:33571674</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7c0q" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 33152]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chen, T T]]
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[[Category: Legionella pneumophila]]
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[[Category: Han, A D]]
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[[Category: Chen TT]]
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[[Category: Luo, Z Q]]
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[[Category: Han AD]]
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[[Category: McCloskey, A]]
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[[Category: Luo ZQ]]
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[[Category: Perri, K]]
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[[Category: McCloskey A]]
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[[Category: Effector]]
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[[Category: Perri K]]
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[[Category: Toxin]]
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Current revision

a Legionella pneumophila effector Lpg2505

PDB ID 7c0q

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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