7c97

==Cryo-EM structure of an Escherichia coli RNAP-promoter open complex (RPo) with SspA==

<StructureSection load='7c97' size='340' side='right'caption='[[7c97]], [[Resolution|resolution]] 3.68&Aring;' scene=''>

<table><tr><td colspan='2'>[[7c97]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C97 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C97 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.68&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c97 OCA], [https://pdbe.org/7c97 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c97 RCSB], [https://www.ebi.ac.uk/pdbsum/7c97 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c97 ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/SSPA_ECOLI SSPA_ECOLI] Forms an equimolar complex with the RNA polymerase holoenzyme (RNAP) but not with the core enzyme. It is synthesized predominantly when cells are exposed to amino acid starvation, at which time it accounts for over 50% of the total protein synthesized. It is involved in the transition from P1 early to P1 late gene expression. Rnk and SspA can functionally replace P.aeruginosa alginate regulatory gene algR2.

==See Also==

*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]

*[[Sigma factor 3D structures|Sigma factor 3D structures]]

*[[Stringent starvation protein 3D structures|Stringent starvation protein 3D structures]]

[[Category: Escherichia coli]]

[[Category: Escherichia coli K-12]]

[[Category: Feng Y]]

[[Category: Lin W]]