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7ca5

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Current revision (10:50, 27 March 2024) (edit) (undo)
 
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====
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==Cryo-EM structure of human GABA(B) receptor in apo state==
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<StructureSection load='7ca5' size='340' side='right'caption='[[7ca5]]' scene=''>
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<StructureSection load='7ca5' size='340' side='right'caption='[[7ca5]], [[Resolution|resolution]] 7.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7ca5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CA5 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7ca5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ca5 OCA], [http://pdbe.org/7ca5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7ca5 RCSB], [http://www.ebi.ac.uk/pdbsum/7ca5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7ca5 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ca5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ca5 OCA], [https://pdbe.org/7ca5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ca5 RCSB], [https://www.ebi.ac.uk/pdbsum/7ca5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ca5 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GABR2_HUMAN GABR2_HUMAN] Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.<ref>PMID:9872316</ref> <ref>PMID:10328880</ref> <ref>PMID:18165688</ref> <ref>PMID:22660477</ref>
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==See Also==
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*[[GABA receptor 3D structures|GABA receptor 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Cho Y]]
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[[Category: Jeong E]]
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[[Category: Jeong J]]
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[[Category: Kim Y]]

Current revision

Cryo-EM structure of human GABA(B) receptor in apo state

PDB ID 7ca5

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