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7d84

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Current revision (10:53, 27 March 2024) (edit) (undo)
 
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<StructureSection load='7d84' size='340' side='right'caption='[[7d84]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
<StructureSection load='7d84' size='340' side='right'caption='[[7d84]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7d84]] is a 34 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_typhimurium"_loeffler_1892 "bacillus typhimurium" loeffler 1892]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D84 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D84 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7d84]] is a 34 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D84 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D84 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fliF, fla AII.1, fla BI, STM1969 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 "Bacillus typhimurium" Loeffler 1892])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d84 OCA], [https://pdbe.org/7d84 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d84 RCSB], [https://www.ebi.ac.uk/pdbsum/7d84 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d84 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d84 OCA], [https://pdbe.org/7d84 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d84 RCSB], [https://www.ebi.ac.uk/pdbsum/7d84 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d84 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/FLIF_SALTY FLIF_SALTY]] The M ring may be actively involved in energy transduction.
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[https://www.uniprot.org/uniprot/FLIF_SALTY FLIF_SALTY] The M ring may be actively involved in energy transduction.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The bacterial flagellar MS ring is a transmembrane complex acting as the core of the flagellar motor and template for flagellar assembly. The C ring attached to the MS ring is involved in torque generation and rotation switch, and a large symmetry mismatch between these two rings has been a long puzzle, especially with respect to their role in motor function. Here, using cryoEM structural analysis of the flagellar basal body and the MS ring formed by full-length FliF from Salmonella enterica, we show that the native MS ring is formed by 34 FliF subunits with no symmetry variation. Symmetry analysis of the C ring shows a variation with a peak at 34-fold, suggesting flexibility in C ring assembly. Finally, our data also indicate that FliF subunits assume two different conformations, contributing differentially to the inner and middle parts of the M ring and thus resulting in 23- and 11-fold subsymmetries in the inner and middle M ring, respectively. The internal core of the M ring, formed by 23 subunits, forms a hole of the right size to accommodate the protein export gate.
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Native flagellar MS ring is formed by 34 subunits with 23-fold and 11-fold subsymmetries.,Kawamoto A, Miyata T, Makino F, Kinoshita M, Minamino T, Imada K, Kato T, Namba K Nat Commun. 2021 Jul 9;12(1):4223. doi: 10.1038/s41467-021-24507-9. PMID:34244518<ref>PMID:34244518</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7d84" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus typhimurium loeffler 1892]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Imada, K]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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[[Category: Kato, T]]
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[[Category: Imada K]]
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[[Category: Kawamoto, A]]
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[[Category: Kato T]]
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[[Category: Kinoshita, M]]
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[[Category: Kawamoto A]]
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[[Category: Makino, F]]
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[[Category: Kinoshita M]]
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[[Category: Minamino, T]]
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[[Category: Makino F]]
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[[Category: Miyata, T]]
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[[Category: Minamino T]]
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[[Category: Namba, K]]
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[[Category: Miyata T]]
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[[Category: Flagellar motor]]
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[[Category: Namba K]]
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[[Category: Membrane protein]]
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[[Category: Torque generation]]
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[[Category: Transmembrane protein complex]]
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[[Category: Type iii protein export system]]
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Current revision

34-fold symmetry Salmonella S ring formed by full-length FliF

PDB ID 7d84

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