7dkg

==Influenza H5N1 nucleoprotein (truncated) in complex with nucleotides==

<StructureSection load='7dkg' size='340' side='right'caption='[[7dkg]], [[Resolution|resolution]] 3.00&Aring;' scene=''>

<table><tr><td colspan='2'>[[7dkg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Chicken/Hong_Kong/786/97_(H5N1)) Influenza A virus (A/Chicken/Hong Kong/786/97 (H5N1))] and [https://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DKG FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dkg OCA], [https://pdbe.org/7dkg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dkg RCSB], [https://www.ebi.ac.uk/pdbsum/7dkg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dkg ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/Q9PX50_9INFA Q9PX50_9INFA] Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus (By similarity).[SAAS:SAAS002141_004_603280]

==See Also==

*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]

[[Category: Unidentified influenza virus]]

[[Category: Xu S]]