7dmb

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Current revision (10:53, 27 March 2024) (edit) (undo)
 
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<StructureSection load='7dmb' size='340' side='right'caption='[[7dmb]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='7dmb' size='340' side='right'caption='[[7dmb]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7dmb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_16819 Atcc 16819]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DMB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DMB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7dmb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_stellatus Aspergillus stellatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DMB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DMB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dmb OCA], [https://pdbe.org/7dmb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dmb RCSB], [https://www.ebi.ac.uk/pdbsum/7dmb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dmb ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dmb OCA], [https://pdbe.org/7dmb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dmb RCSB], [https://www.ebi.ac.uk/pdbsum/7dmb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dmb ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A0A679DLY7_EMEVA A0A679DLY7_EMEVA]
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Calbistrins are fungal polyketides consisting of the characteristic decalin and polyene moieties. Although the biosynthetic gene cluster of calbistrin A was recently identified, the pathway of calbistrin A biosynthesis has largely remained uninvestigated. Herein, we investigated the mechanism by which the backbone structures of calbistrins are formed, by heterologous and in vitro reconstitution of the biosynthesis and a structural biological study. Intriguingly, our analyses revealed that the decalin and polyene portions of calbistrins are synthesized by the single polyketide synthase (PKS) CalA, with the aid of the trans-acting enoylreductase CalK and the trans-acting methyltransferase CalH, respectively. We also determined that the esterification of the two polyketide parts is catalyzed by the acyltransferase CalD. Our study has uncovered a novel dual-functional PKS and thus broadened our understanding of how fungi synthesize diverse polyketide natural products.
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One Polyketide Synthase, Two Distinct Products: Trans-Acting Enzyme-Controlled Product Divergence in Calbistrin Biosynthesis.,Abe I, Tao H, Mori T, Wei X, Matsuda Y Angew Chem Int Ed Engl. 2021 Jan 22. doi: 10.1002/anie.202016525. PMID:33480463<ref>PMID:33480463</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7dmb" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 16819]]
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[[Category: Aspergillus stellatus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Abe, I]]
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[[Category: Abe I]]
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[[Category: Mori, T]]
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[[Category: Mori T]]
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[[Category: Tao, H]]
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[[Category: Tao H]]
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[[Category: Calbistrin a biosynthesis]]
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[[Category: Calh]]
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[[Category: Methyltransferase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of trans-methyltransferase CalH complex with SAH

PDB ID 7dmb

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