1gcf

<StructureSection load='1gcf' size='340' side='right'caption='[[1gcf]], [[NMR_Ensembles_of_Models | 12 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[1gcf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GCF FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gcf OCA], [https://pdbe.org/1gcf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gcf RCSB], [https://www.ebi.ac.uk/pdbsum/1gcf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gcf ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/CSF3R_MOUSE CSF3R_MOUSE]] Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface.

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== Publication Abstract from PubMed ==

We have determined the NMR structure of a ligand-binding domain of the granulocyte colony-stimulating factor (G-CSF) receptor, containing the highly conserved WSxWS motif. The domain consists of seven beta-strands with the fibronectin type III-like topology seen in several cytokine receptors. Comparisons between the spectra of the 15N-labelled domain with and without G-CSF indicate that the major ligand-recognition site is on the FG loop just upstream of the WSxWS sequence, and not on the BC loop which is mainly used in the growth hormone system. The WSxWS residues are suggested to contribute to ligand-recognition and to the protein architecture of the G-CSF receptor.

Solution structure of an extracellular domain containing the WSxWS motif of the granulocyte colony-stimulating factor receptor and its interaction with ligand.,Yamasaki K, Naito S, Anaguchi H, Ohkubo T, Ota Y Nat Struct Biol. 1997 Jun;4(6):498-504. PMID:9187659<ref>PMID:9187659</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Lk3 transgenic mice]]

[[Category: Anaguchi, H]]

[[Category: Naito, S]]

[[Category: Ohkubo, T]]

[[Category: Ota, Y]]

[[Category: Yamasaki, K]]

[[Category: Cytokine receptor]]