1go3
From Proteopedia
(Difference between revisions)
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<StructureSection load='1go3' size='340' side='right'caption='[[1go3]], [[Resolution|resolution]] 1.75Å' scene=''> | <StructureSection load='1go3' size='340' side='right'caption='[[1go3]], [[Resolution|resolution]] 1.75Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1go3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1go3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GO3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GO3 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1go3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1go3 OCA], [https://pdbe.org/1go3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1go3 RCSB], [https://www.ebi.ac.uk/pdbsum/1go3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1go3 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1go3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1go3 OCA], [https://pdbe.org/1go3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1go3 RCSB], [https://www.ebi.ac.uk/pdbsum/1go3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1go3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/RPO7_METJA RPO7_METJA] DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_00865] | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1go3 ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1go3 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | The eukaryotic subunits RPB4 and RPB7 form a heterodimer that reversibly associates with the RNA polymerase II core and constitute the only two components of the enzyme for which no structural information is available. We have determined the crystal structure of the complex between the Methanococcus jannaschii subunits E and F, the archaeal homologs of RPB7 and RPB4. Subunit E has an elongated two-domain structure and contains two potential RNA binding motifs, while the smaller F subunit wraps around one side of subunit E, at the interface between the two domains. We propose a model for the interaction between RPB4/RPB7 and the core RNA polymerase in which the RNA binding face of RPB7 is positioned to interact with the nascent RNA transcript. | ||
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| - | Structure of an archaeal homolog of the eukaryotic RNA polymerase II RPB4/RPB7 complex.,Todone F, Brick P, Werner F, Weinzierl RO, Onesti S Mol Cell. 2001 Nov;8(5):1137-43. PMID:11741548<ref>PMID:11741548</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 1go3" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]] | *[[RNA polymerase 3D structures|RNA polymerase 3D structures]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Atcc 43067]] | ||
| - | [[Category: DNA-directed RNA polymerase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Brick | + | [[Category: Methanocaldococcus jannaschii]] |
| - | [[Category: Onesti | + | [[Category: Brick P]] |
| - | [[Category: Todone | + | [[Category: Onesti S]] |
| - | [[Category: Weinzierl | + | [[Category: Todone F]] |
| - | [[Category: Werner | + | [[Category: Weinzierl ROJ]] |
| - | + | [[Category: Werner F]] | |
| - | + | ||
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Revision as of 11:23, 27 March 2024
Structure of an archeal homolog of the eukaryotic RNA polymerase II RPB4/RPB7 complex
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