1h4u

<table><tr><td colspan='2'>[[1h4u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H4U FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h4u OCA], [https://pdbe.org/1h4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h4u RCSB], [https://www.ebi.ac.uk/pdbsum/1h4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h4u ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/NID1_MOUSE NID1_MOUSE]] Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.

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== Publication Abstract from PubMed ==

Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. Here, we report the crystal structure of the mouse nidogen-1 G2 fragment, which contains binding sites for collagen IV and perlecan. The structure is composed of an EGF-like domain and an 11-stranded beta-barrel with a central helix. The beta-barrel domain has unexpected similarity to green fluorescent protein. A large surface patch on the beta-barrel is strikingly conserved in all metazoan nidogens. Site-directed mutagenesis demonstrates that the conserved residues are involved in perlecan binding.

Crystal structure and mutational analysis of a perlecan-binding fragment of nidogen-1.,Hopf M, Gohring W, Ries A, Timpl R, Hohenester E Nat Struct Biol. 2001 Jul;8(7):634-40. PMID:11427896<ref>PMID:11427896</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Lk3 transgenic mice]]

[[Category: Gohring, W]]

[[Category: Hohenester, E]]

[[Category: Hopf, M]]

[[Category: Ries, A]]

[[Category: Timpl, R]]

[[Category: Extracellular matrix protein]]