1h8m
From Proteopedia
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==Solution structure of ykt6== | ==Solution structure of ykt6== | ||
| - | <StructureSection load='1h8m' size='340' side='right'caption='[[1h8m | + | <StructureSection load='1h8m' size='340' side='right'caption='[[1h8m]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1h8m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H8M FirstGlance]. <br> | <table><tr><td colspan='2'>[[1h8m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H8M FirstGlance]. <br> | ||
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8m OCA], [https://pdbe.org/1h8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h8m RCSB], [https://www.ebi.ac.uk/pdbsum/1h8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h8m ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8m OCA], [https://pdbe.org/1h8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h8m RCSB], [https://www.ebi.ac.uk/pdbsum/1h8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h8m ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/YKT6_YEAST YKT6_YEAST] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h8m ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h8m ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Ykt6p is a nonsyntaxin SNARE implicated in multiple intracellular membrane trafficking steps. Here we present the structure of the NH2-terminal domain of Ykt6p (Ykt6pN, residues 1 to 140). The structure of Ykt6pN differed entirely from that of syntaxin and resembled the overall fold of the actin regulatory protein, profilin. Like some syntaxins, Ykt6p adopted a folded back conformation in which Ykt6pN bound to its COOH-terminal core domain. The NH2-terminal domain plays an important biological role in the function of Ykt6p, which in vitro studies revealed to include influencing the kinetics and proper assembly of SNARE complexes. | ||
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| - | An autoinhibitory mechanism for nonsyntaxin SNARE proteins revealed by the structure of Ykt6p.,Tochio H, Tsui MM, Banfield DK, Zhang M Science. 2001 Jul 27;293(5530):698-702. PMID:11474112<ref>PMID:11474112</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 1h8m" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| - | [[Category: Banfield | + | [[Category: Banfield DK]] |
| - | [[Category: Tochio | + | [[Category: Tochio H]] |
| - | [[Category: Tsui | + | [[Category: Tsui MMK]] |
| - | [[Category: Zhang | + | [[Category: Zhang M]] |
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Revision as of 11:29, 27 March 2024
Solution structure of ykt6
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