1he9

<table><tr><td colspan='2'>[[1he9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HE9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1HE9 FirstGlance]. <br>

</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1he1|1he1]]</td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EXOS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1he9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1he9 OCA], [http://pdbe.org/1he9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1he9 RCSB], [http://www.ebi.ac.uk/pdbsum/1he9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1he9 ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Pseudomonas aeruginosa is an opportunistic bacterial pathogen of great medical relevance. One of its major toxins, exoenzyme S (ExoS), is a dual function protein with a C-terminal Ras-ADP-ribosylation domain and an N-terminal GTPase activating protein (GAP) domain specific for Rho-family proteins. We report here the three-dimensional structure of the N-terminal domain of ExoS determined by X-ray crystallography to 2.4 A resolution. Its fold is all helical with a four helix bundle core capped by additional irregular helices. Loops that are known to interact with Rho-family proteins show very large mobility. Considering the importance of ExoS in Pseudomonas pathogenicity, this structure could be of interest for drug targeting.

Structure of the ExoS GTPase activating domain.,Wurtele M, Renault L, Barbieri JT, Wittinghofer A, Wolf E FEBS Lett. 2001 Feb 23;491(1-2):26-9. PMID:11226412<ref>PMID:11226412</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1he9" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Barbieri, J T]]

[[Category: Renault, L]]

[[Category: Wittinghofer, A]]

[[Category: Wolf, E]]

[[Category: Wurtele, M]]

[[Category: Exo]]

[[Category: Gap]]

[[Category: Signal transduction]]

[[Category: Toxin]]

[[Category: Virulence factor]]