1hq8

<table><tr><td colspan='2'>[[1hq8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HQ8 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hq8 OCA], [https://pdbe.org/1hq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hq8 RCSB], [https://www.ebi.ac.uk/pdbsum/1hq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hq8 ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/NKG2D_MOUSE NKG2D_MOUSE]] Receptor for RAET1A, RAET1B, RAET1C, RAET1D, RAET1E, H60 and MULT1. Involved in the immune surveillance exerted by T and B lymphocytes.<ref>PMID:12370332</ref>

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== Publication Abstract from PubMed ==

NKG2D, a homodimeric lectin-like receptor, is a unique stimulatory molecule that is found on natural killer cells,T cells and activated macrophages.The natural ligands for murine NKG2D are distant major histocompatibility complex homologs, retinoic acid early transcript (Rae1) and H-60 minor histocompatibility antigen. The crystal structure of the extracellular region of murine NKG2D reveals close homology with other C-type lectin receptors such as CD94, Ly49A, rat MBP-A and CD69. However, the precise mode of dimeric assembly varies among these natural killer receptors, as well as their surface topography and electrostatic properties.The NKG2D structure provides the first structural insights into the role and ligand specificity of this stimulatory receptor in the innate and adaptive immune system.

Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A.,Wolan DW, Teyton L, Rudolph MG, Villmow B, Bauer S, Busch DH, Wilson IA Nat Immunol. 2001 Mar;2(3):248-54. PMID:11224525<ref>PMID:11224525</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1hq8" style="background-color:#fffaf0;"></div>

[[Category: Lk3 transgenic mice]]

[[Category: Bauer, S]]

[[Category: Busch, D H]]

[[Category: Rudolph, M G]]

[[Category: Teyton, L]]

[[Category: Villmow, B]]

[[Category: Wilson, I A]]

[[Category: Wolan, D W]]

[[Category: Homodimer]]