1hv2

<StructureSection load='1hv2' size='340' side='right'caption='[[1hv2]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[1hv2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HV2 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hv2 OCA], [https://pdbe.org/1hv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hv2 RCSB], [https://www.ebi.ac.uk/pdbsum/1hv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hv2 ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/ELOC_YEAST ELOC_YEAST]] Prevents degradation of interacting proteins like PCL6 by the proteasome.<ref>PMID:11864988</ref> [[https://www.uniprot.org/uniprot/VHL_MOUSE VHL_MOUSE]] Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2 (By similarity).

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== Publication Abstract from PubMed ==

Elongin is a transcription elongation factor that stimulates the rate of elongation by suppressing transient pausing by RNA polymerase II at many sites along the DNA. It is heterotrimeric in mammals, consisting of elongins A, B and C subunits, and bears overall similarity to a class of E3 ubiquitin ligases known as SCF (Skp1-Cdc53 (cullin)-F-box) complexes. A subcomplex of elongins B and C is a target for negative regulation by the von Hippel-Lindau (VHL) tumor-suppressor protein. Elongin C from Saccharomyces cerevisiae, Elc1, exhibits high sequence similarity to mammalian elongin C. Using NMR spectroscopy we have determined the three-dimensional structure of Elc1 in complex with a human VHL peptide, VHL(157-171), representing the major Elc1 binding site. The bound VHL peptide is entirely helical. Elc1 utilizes two C-terminal helices and an intervening loop to form a binding groove that fits VHL(157-171). Chemical shift perturbation and dynamics analyses reveal that a global conformational change accompanies Elc1/VHL(157-171) complex formation. Moreover, the disappearance of conformational exchange phenomena on the microsecond to millisecond time scale within Elc1 upon VHL peptide binding suggests a role for slow internal motions in ligand recognition.

Solution structure and dynamics of yeast elongin C in complex with a von Hippel-Lindau peptide.,Botuyan MV, Mer G, Yi GS, Koth CM, Case DA, Edwards AM, Chazin WJ, Arrowsmith CH J Mol Biol. 2001 Sep 7;312(1):177-86. PMID:11545595<ref>PMID:11545595</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1hv2" style="background-color:#fffaf0;"></div>

[[Category: Atcc 18824]]

[[Category: Arrowsmith, C H]]

[[Category: Botuyan, M V]]

[[Category: Case, D A]]

[[Category: Chazin, W J]]

[[Category: Edwards, A M]]

[[Category: Koth, C M]]

[[Category: Mer, G]]

[[Category: Yi, G S]]

[[Category: Protein-peptide complex]]

[[Category: Signaling protein]]