User:Mandy Bechman/Sandbox 1
From Proteopedia
(Difference between revisions)
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<StructureSection load='7ra3' size='340' side='right' caption='GIP Overview' scene='10/1038867/Structure_overview/3'> | <StructureSection load='7ra3' size='340' side='right' caption='GIP Overview' scene='10/1038867/Structure_overview/3'> | ||
==Introduction== | ==Introduction== | ||
| + | Glucose-dependent insulinotropic polypeptide (GIP) is a gastric inhibitory polypeptide. It is categorized as a incretin, which is a gut-based hormone that is secreted upon the ingestion of food. It is found in K cells in the upper small intestines of humans. | ||
===History=== | ===History=== | ||
| + | The idea of incretin began in 1902 after the discovery of secretin | ||
==Structure Overview== | ==Structure Overview== | ||
GIP is a G-coupled receptor. It is composed of the alpha, beta, and gamma subunits. | GIP is a G-coupled receptor. It is composed of the alpha, beta, and gamma subunits. | ||
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</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
| - | <ref name=" | + | <ref name="Seino>PMID:24843404</ref>. |
<ref name="Mayendraraj>PMID:35065096</ref>. | <ref name="Mayendraraj>PMID:35065096</ref>. | ||
<references/> | <references/> | ||
Revision as of 14:21, 28 March 2024
H. sapiens Glucose-dependent Insulinotropic Polypeptide
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Seino Y, Fukushima M, Yabe D. GIP and GLP-1, the two incretin hormones: Similarities and differences. J Diabetes Investig. 2010 Apr 22;1(1-2):8-23. PMID:24843404 doi:10.1111/j.2040-1124.2010.00022.x
- ↑ Mayendraraj A, Rosenkilde MM, Gasbjerg LS. GLP-1 and GIP receptor signaling in beta cells interactions and co-stimulation. Peptides. 2022 May;151:170749. PMID:35065096 doi:10.1016/j.peptides.2022.170749
