Cefoxitin
From Proteopedia
(Difference between revisions)
| Line 2: | Line 2: | ||
Cefoxitin is a second-generation cephamycin antibiotic developed by Merck & Co., Inc. from Cephamycin C in the year following its discovery, 1972. See also [https://en.wikipedia.org/wiki/Cefoxitin Cefoxitin]. | Cefoxitin is a second-generation cephamycin antibiotic developed by Merck & Co., Inc. from Cephamycin C in the year following its discovery, 1972. See also [https://en.wikipedia.org/wiki/Cefoxitin Cefoxitin]. | ||
| - | Cefoxitin is a beta-lactam antibiotic which binds to penicillin binding proteins, or transpeptidases. By binding to PBPs, cefoxitin prevents the PBPs from forming the cross-linkages between the peptidoglycan layers that make up the bacterial cell wall, thereby interfering with cell wall synthesis. It is a strong beta-lactamase inducer, as are certain other antibiotics (such as imipenem). However, cefoxitin is a better substrate than imipenem for beta-lactamases. | + | Cefoxitin is a beta-lactam antibiotic which binds to penicillin binding proteins, or transpeptidases. By binding to PBPs, cefoxitin prevents the PBPs from forming the cross-linkages between the peptidoglycan layers that make up the bacterial cell wall, thereby interfering with cell wall synthesis. It is a strong beta-lactamase inducer, as are certain other antibiotics (such as imipenem). However, cefoxitin is a better substrate than imipenem for beta-lactamases.<ref name="a10">PMID:8477758</ref> |
<scene name='10/1040131/Cv/2'>S. aureus penicillin-binding protein 4 (PBP4) in complex with cefoxitin</scene> ([[7kcx]]). | <scene name='10/1040131/Cv/2'>S. aureus penicillin-binding protein 4 (PBP4) in complex with cefoxitin</scene> ([[7kcx]]). | ||
Revision as of 14:53, 28 March 2024
| |||||||||||
References
- ↑ Phillips I, Shannon K. Importance of beta-lactamase induction. Eur J Clin Microbiol Infect Dis. 1993;12 Suppl 1:S19-26. PMID:8477758 doi:10.1007/BF02389873
