This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
User:SaraKathryn Kalkhoff/Sandbox 1
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Introduction == | == Introduction == | ||
| + | [https://www.sciencedirect.com/topics/medicine-and-dentistry/gastric-inhibitory-polypeptide GIP-R is a receptor that binds glucose within many different cells.] | ||
| + | [[Image:Gip.png|300px|right|thumb|Figure 1: Main Structure of the Glucose Depending Insulinotropic Receptor (GIP-R).]] | ||
| - | [[Image:Gip.png|300px|right|thumb|Figure 1: Main Structure of the Glucose Depending Insulinotropic Receptor (GIP-R).]] | ||
| - | [https://www.sciencedirect.com/topics/medicine-and-dentistry/gastric-inhibitory-polypeptide GIP-R is a receptor that binds glucose within many different cells.] | ||
== Function == | == Function == | ||
The GIP receptor helps facilitate movement of glucose within a cell. <ref name='Sun'>PMID:35333651</ref>. | The GIP receptor helps facilitate movement of glucose within a cell. <ref name='Sun'>PMID:35333651</ref>. | ||
| Line 18: | Line 18: | ||
<scene name='10/1037492/Gip_tirz/2'>Main scene of Tirzepatide bound to the GIP receptor. </scene> | <scene name='10/1037492/Gip_tirz/2'>Main scene of Tirzepatide bound to the GIP receptor. </scene> | ||
=== Active Site === | === Active Site === | ||
| - | + | Main binding domains between tirzepatide and the GIP receptor would contain an arginine 190 and glutamine 220 residues to facilitate binding of the ligand. One key difference found was a point mutation at position 7 between an Isoleucine and Threonine <ref name='Sun'>PMID:35333651</ref>, which would result in a higher affinity for the tirzepatide molecule binding onto the receptor than the ligand. | |
| - | + | [[Image:i7_vs_t7.png|300px|left|thumb|Figure 2: Key difference between GIP ligand and Tirzepatide at position 7. Ile7 is in pink (ligand), and Thr7 is in green (tirzepatide).]] | |
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 13:27, 2 April 2024
Glucose-Dependent Insulinotropic Receptor/GIPR bound with Tirzepatide
| |||||||||||
