1rfb

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[[Image:1rfb.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rfb OCA], [http://www.ebi.ac.uk/pdbsum/1rfb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rfb RCSB]</span>
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'''CRYSTAL STRUCTURE OF RECOMBINANT BOVINE INTERFERON-GAMMA AT 3.0 ANGSTROMS RESOLUTION'''
'''CRYSTAL STRUCTURE OF RECOMBINANT BOVINE INTERFERON-GAMMA AT 3.0 ANGSTROMS RESOLUTION'''
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[[Category: Rubin, J R.]]
[[Category: Rubin, J R.]]
[[Category: Samudzi, C T.]]
[[Category: Samudzi, C T.]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:25:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:27:19 2008''
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Revision as of 04:25, 3 May 2008

Image:1rfb.gif

Template:STRUCTURE 1rfb

CRYSTAL STRUCTURE OF RECOMBINANT BOVINE INTERFERON-GAMMA AT 3.0 ANGSTROMS RESOLUTION


Overview

The three-dimensional crystal structure of recombinant bovine interferon-gamma was determined using the multiple isomorphous replacement method at 3.0 A and refined to an R factor of 19.2%. This protein crystallizes in space group P2(1)2(1)2(1) with unit-cell parameters of a = 42.8, b = 79.9 and c = 85.4 A. There is one functional dimer in the asymmetric unit. The two polypeptide chains are related by a non-crystallographic twofold symmetry axis. The secondary structure is predominantly alpha-helical with extensive interdigitation of the alpha-helical segments of the polypeptide chains that make up the dimer. The secondary structure, tertiary structure and topology of this molecule are identical to the previously reported structures of recombinant rabbit interferon-gamma and recombinant human interferon-gamma. The molecular topology is also similar to that of murine interferon-beta. These structural similarities strongly indicate the presence of a unique topological feature (fold) among gamma-interferons from different species, and also among the different classes of interferons.

About this Structure

1RFB is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structure of recombinant bovine interferon-gamma at 3.0 A resolution., Samudzi CT, Rubin JR, Acta Crystallogr D Biol Crystallogr. 1993 Nov 1;49(Pt 6):513-21. PMID:15299487 Page seeded by OCA on Sat May 3 07:25:38 2008

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