8j6i

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'''Unreleased structure'''
 
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The entry 8j6i is ON HOLD until Paper Publication
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==Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound MK-6892==
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<StructureSection load='8j6i' size='340' side='right'caption='[[8j6i]], [[Resolution|resolution]] 2.92&Aring;' scene=''>
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Authors: Yuan, Q., Zhu, S., Duan, J., Xu, H.E., Duan, X.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8j6i]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J6I FirstGlance]. <br>
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Description: Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound MK-6892
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.92&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FI7:2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic+acid'>FI7</scene></td></tr>
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[[Category: Duan, X]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j6i OCA], [https://pdbe.org/8j6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j6i RCSB], [https://www.ebi.ac.uk/pdbsum/8j6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j6i ProSAT]</span></td></tr>
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[[Category: Xu, H.E]]
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</table>
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[[Category: Duan, J]]
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== Function ==
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[[Category: Yuan, Q]]
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[https://www.uniprot.org/uniprot/HCAR2_HUMAN HCAR2_HUMAN] Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.<ref>PMID:17932499</ref>
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[[Category: Zhu, S]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Duan J]]
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[[Category: Duan X]]
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[[Category: Xu HE]]
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[[Category: Yuan Q]]
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[[Category: Zhu S]]

Revision as of 05:46, 3 April 2024

Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound MK-6892

PDB ID 8j6i

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