1rfx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1rfx.gif|left|200px]]
[[Image:1rfx.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1rfx |SIZE=350|CAPTION= <scene name='initialview01'>1rfx</scene>, resolution 2.002&Aring;
+
The line below this paragraph, containing "STRUCTURE_1rfx", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= RETN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+
-->
-
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam06954 Resistin]</span>
+
{{STRUCTURE_1rfx| PDB=1rfx | SCENE= }}
-
|RELATEDENTRY=[[1rgx|1RGX]], [[1rh7|1RH7]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rfx OCA], [http://www.ebi.ac.uk/pdbsum/1rfx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rfx RCSB]</span>
+
-
}}
+
'''Crystal Structure of resisitin'''
'''Crystal Structure of resisitin'''
Line 31: Line 28:
[[Category: Scherer, P E.]]
[[Category: Scherer, P E.]]
[[Category: Shapiro, L.]]
[[Category: Shapiro, L.]]
-
[[Category: glucose uptake]]
+
[[Category: Glucose uptake]]
-
[[Category: hormone]]
+
[[Category: Hormone]]
-
[[Category: new york structural genomix research consortium]]
+
[[Category: New york structural genomix research consortium]]
-
[[Category: nysgxrc]]
+
[[Category: Nysgxrc]]
-
[[Category: protein structure initiative]]
+
[[Category: Protein structure initiative]]
-
[[Category: psi]]
+
[[Category: Psi]]
-
[[Category: resistin/fizz family]]
+
[[Category: Resistin/fizz family]]
-
[[Category: structural genomic]]
+
[[Category: Structural genomic]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:26:57 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:27:37 2008''
+

Revision as of 04:26, 3 May 2008

Image:1rfx.gif

Template:STRUCTURE 1rfx

Crystal Structure of resisitin


Overview

Resistin, founding member of the resistin-like molecule (RELM) hormone family, is secreted selectively from adipocytes and induces liver-specific antagonism of insulin action, thus providing a potential molecular link between obesity and diabetes. Crystal structures of resistin and RELMbeta reveal an unusual multimeric structure. Each protomer comprises a carboxy-terminal disulfide-rich beta-sandwich "head" domain and an amino-terminal alpha-helical "tail" segment. The alpha-helical segments associate to form three-stranded coiled coils, and surface-exposed interchain disulfide linkages mediate the formation of tail-to-tail hexamers. Analysis of serum samples shows that resistin circulates in two distinct assembly states, likely corresponding to hexamers and trimers. Infusion of a resistin mutant, lacking the intertrimer disulfide bonds, in pancreatic-insulin clamp studies reveals substantially more potent effects on hepatic insulin sensitivity than those observed with wild-type resistin. This result suggests that processing of the intertrimer disulfide bonds may reflect an obligatory step toward activation.

About this Structure

1RFX is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Disulfide-dependent multimeric assembly of resistin family hormones., Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L, Science. 2004 May 21;304(5674):1154-8. PMID:15155948 Page seeded by OCA on Sat May 3 07:26:57 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1rfx"
Personal tools