1jeo

<table><tr><td colspan='2'>[[1jeo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43067 Atcc 43067]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JEO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1JEO FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mj1247 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 ATCC 43067])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1jeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jeo OCA], [http://pdbe.org/1jeo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jeo RCSB], [http://www.ebi.ac.uk/pdbsum/1jeo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jeo ProSAT], [http://www.topsan.org/Proteins/BSGC/1jeo TOPSAN]</span></td></tr>

[[http://www.uniprot.org/uniprot/PHI_METJA PHI_METJA]] Catalyzes the isomerization between 3-hexulose 6-phosphate and fructose 6-phosphate.<ref>PMID:11839305</ref>

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== Publication Abstract from PubMed ==

The crystal structure of the hypothetical protein MJ1247 from Methanococccus jannaschii at 2 A resolution, a detailed sequence analysis, and biochemical assays infer its molecular function to be 3-hexulose-6-phosphate isomerase (PHI). In the dissimilatory ribulose monophosphate (RuMP) cycle, ribulose-5-phosphate is coupled to formaldehyde by the 3-hexulose-6-phosphate synthase (HPS), yielding hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by the enzyme 3-hexulose-6-phosphate isomerase. MJ1247 is an alpha/beta structure consisting of a five-stranded parallel beta sheet flanked on both sides by alpha helices, forming a three-layered alpha-beta-alpha sandwich. The fold represents the nucleotide binding motif of a flavodoxin type. MJ1247 is a tetramer in the crystal and in solution and each monomer has a folding similar to the isomerase domain of glucosamine-6-phosphate synthase (GlmS).

Crystal structure of MJ1247 protein from M. jannaschii at 2.0 A resolution infers a molecular function of 3-hexulose-6-phosphate isomerase.,Martinez-Cruz LA, Dreyer MK, Boisvert DC, Yokota H, Martinez-Chantar ML, Kim R, Kim SH Structure. 2002 Feb;10(2):195-204. PMID:11839305<ref>PMID:11839305</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1jeo" style="background-color:#fffaf0;"></div>

[[Category: Atcc 43067]]

[[Category: Structural genomic]]

[[Category: Boisvert, D C]]

[[Category: Dreyer, M K]]

[[Category: Kim, R]]

[[Category: Kim, S H]]

[[Category: Martinez-Chantar, M L]]

[[Category: Martinez-Cruz, L A]]

[[Category: Yokota, H]]

[[Category: Rump pathway]]