3ht2
From Proteopedia
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<StructureSection load='3ht2' size='340' side='right'caption='[[3ht2]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='3ht2' size='340' side='right'caption='[[3ht2]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3ht2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3ht2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_resistomycificus Streptomyces resistomycificus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HT2 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ht2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ht2 OCA], [https://pdbe.org/3ht2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ht2 RCSB], [https://www.ebi.ac.uk/pdbsum/3ht2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ht2 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ht2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ht2 OCA], [https://pdbe.org/3ht2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ht2 RCSB], [https://www.ebi.ac.uk/pdbsum/3ht2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ht2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q70DX5_9ACTN Q70DX5_9ACTN] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ht2 ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ht2 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | RemF is a polyketide cyclase involved in the biosynthesis of the aromatic pentacyclic metabolite resistomycin in Streptomyces resistomycificus. The enzyme is a member of a structurally hitherto uncharacterized class of polyketide cyclases. The crystal structure of RemF was determined by SAD and refined to 1.2 A resolution. The enzyme subunit shows a beta-sandwich structure with a topology characteristic for the cupin fold. RemF contains a metal binding site located at the bottom of the predominantly hydrophobic active site cavity. A zinc ion is coordinated to four histidine side chains, and two water molecules in octahedral ligand sphere geometry, highly unusual for zinc binding sites in proteins. | ||
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| - | The polyketide cyclase RemF from Streptomyces resistomycificus contains an unusual octahedral zinc binding site.,Silvennoinen L, Sandalova T, Schneider G FEBS Lett. 2009 Sep 3;583(17):2917-21. Epub 2009 Aug 6. PMID:19665022<ref>PMID:19665022</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 3ht2" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Atcc 19804]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Streptomyces resistomycificus]] |
| - | [[Category: | + | [[Category: Sandalova T]] |
| - | [[Category: | + | [[Category: Schneider G]] |
| - | [[Category: | + | [[Category: Silvennoinen L]] |
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Revision as of 06:38, 3 April 2024
Zink containing polyketide cyclase RemF from Streptomyces resistomycificus
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