3x29

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<StructureSection load='3x29' size='340' side='right'caption='[[3x29]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
<StructureSection load='3x29' size='340' side='right'caption='[[3x29]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3x29]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_perfringens"_veillon_and_zuber_1898 "bacillus perfringens" veillon and zuber 1898] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3X29 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3x29]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3X29 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cldn19 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), cpe ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1502 "Bacillus perfringens" Veillon and Zuber 1898])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3x29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x29 OCA], [https://pdbe.org/3x29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3x29 RCSB], [https://www.ebi.ac.uk/pdbsum/3x29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3x29 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3x29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x29 OCA], [https://pdbe.org/3x29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3x29 RCSB], [https://www.ebi.ac.uk/pdbsum/3x29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3x29 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CLD19_MOUSE CLD19_MOUSE]] Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. [[https://www.uniprot.org/uniprot/ELTB_CLOPF ELTB_CLOPF]] This enterotoxin is responsible for many cases of a mild type of food poisoning.
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[https://www.uniprot.org/uniprot/CLD19_MOUSE CLD19_MOUSE] Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The C-terminal region of Clostridium perfringens enterotoxin (C-CPE) can bind to specific claudins, resulting in the disintegration of tight junctions (TJs) and an increase in the paracellular permeability across epithelial cell sheets. Here we present the structure of mammalian claudin-19 in complex with C-CPE at 3.7 A resolution. The structure shows that C-CPE forms extensive hydrophobic and hydrophilic interactions with the two extracellular segments of claudin-19. The claudin-19/C-CPE complex shows no density of a short extracellular helix that is critical for claudins to assemble into TJ strands. The helix displacement may thus underlie C-CPE-mediated disassembly of TJs.
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Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin.,Saitoh Y, Suzuki H, Tani K, Nishikawa K, Irie K, Ogura Y, Tamura A, Tsukita S, Fujiyoshi Y Science. 2015 Feb 13;347(6223):775-8. doi: 10.1126/science.1261833. PMID:25678664<ref>PMID:25678664</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3x29" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus perfringens veillon and zuber 1898]]
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[[Category: Clostridium perfringens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Fujiyoshi, Y]]
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[[Category: Fujiyoshi Y]]
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[[Category: Irie, K]]
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[[Category: Irie K]]
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[[Category: Nishikawa, K]]
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[[Category: Nishikawa K]]
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[[Category: Ogura, Y]]
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[[Category: Ogura Y]]
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[[Category: Saitoh, Y]]
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[[Category: Saitoh Y]]
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[[Category: Suzuki, H]]
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[[Category: Suzuki H]]
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[[Category: Tamura, A]]
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[[Category: Tamura A]]
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[[Category: Tani, K]]
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[[Category: Tani K]]
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[[Category: Tsukita, S]]
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[[Category: Tsukita S]]
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[[Category: Cell adhesion]]
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[[Category: Enterotoxin]]
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[[Category: Membrane protein]]
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[[Category: Receptor binding]]
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[[Category: Tight junction]]
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[[Category: Toxin-cell adhesion complex]]
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Revision as of 06:46, 3 April 2024

CRYSTAL STRUCTURE of MOUSE CLAUDIN-19 IN COMPLEX with C-TERMINAL FRAGMENT OF CLOSTRIDIUM PERFRINGENS ENTEROTOXIN

PDB ID 3x29

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