5she

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'''Unreleased structure'''
 
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The entry 5she is ON HOLD until 2024-02-01
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==Crystal Structure of human phosphodiesterase 10 in complex with 2,3-dimethylquinoxalin-6-amine==
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<StructureSection load='5she' size='340' side='right'caption='[[5she]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5she]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SHE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SHE FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=JD6:2,3-dimethylquinoxalin-6-amine'>JD6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5she FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5she OCA], [https://pdbe.org/5she PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5she RCSB], [https://www.ebi.ac.uk/pdbsum/5she PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5she ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Benz J]]
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[[Category: Flohr A]]
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[[Category: Joseph C]]
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[[Category: Kumagai Y]]
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[[Category: Rudolph MG]]

Revision as of 06:59, 3 April 2024

Crystal Structure of human phosphodiesterase 10 in complex with 2,3-dimethylquinoxalin-6-amine

PDB ID 5she

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