6uc5

<table><tr><td colspan='2'>[[6uc5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UC5 FirstGlance]. <br>

</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uc5 OCA], [http://pdbe.org/6uc5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uc5 RCSB], [http://www.ebi.ac.uk/pdbsum/6uc5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uc5 ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Malaria vaccine candidate RTS,S/AS01 is based on the central and C-terminal regions of the circumsporozoite protein (CSP) of P. falciparum. mAb397 was isolated from a volunteer in an RTS,S/AS01 clinical trial, and it protects mice from infection by malaria sporozoites. However, mAb397 originates from the less commonly used VH3-15 germline gene compared to the VH3-30/33 antibodies generally elicited by RTS,S to the central NANP repeat region of CSP. The crystal structure of mAb397 with an NPNA4 peptide shows that the central NPNA forms a type I beta-turn and is the main recognition motif. In most anti-NANP antibodies studied to date, a germline-encoded Trp is used to engage the Pro in NPNA beta-turns, but here the Trp interacts with the first Asn. This "conserved" Trp, however, can arise from different germline genes and be located in the heavy or the light chain. Variation in the terminal psi angles of the NPNA beta-turns results in different dispositions of the subsequent NPNA and, hence, different stoichiometries and modes of antibody binding to rsCSP. Diverse protective antibodies against NANP repeats are therefore not limited to a single germline gene response or mode of binding.

 

== References ==

[[Category: Human]]

[[Category: Oyen, D]]

[[Category: Pholcharee, T]]

[[Category: Wilson, I A]]

[[Category: Antibody]]

[[Category: Plasmodium falciparum]]