7lul
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==Structure of the MM2 Erbin PDZ variant in complex with a high-affinity peptide== |
| - | <StructureSection load='7lul' size='340' side='right'caption='[[7lul]]' scene=''> | + | <StructureSection load='7lul' size='340' side='right'caption='[[7lul]], [[Resolution|resolution]] 1.65Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7lul]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=6ubg 6ubg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LUL FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lul OCA], [https://pdbe.org/7lul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lul RCSB], [https://www.ebi.ac.uk/pdbsum/7lul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lul ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lul OCA], [https://pdbe.org/7lul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lul RCSB], [https://www.ebi.ac.uk/pdbsum/7lul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lul ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ERBIN_HUMAN ERBIN_HUMAN] Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728).<ref>PMID:10878805</ref> <ref>PMID:16203728</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Synthetic construct]] |
| + | [[Category: Ernst A]] | ||
| + | [[Category: McLaughlin M]] | ||
| + | [[Category: Sicheri F]] | ||
| + | [[Category: Sidhu SS]] | ||
| + | [[Category: Singer AU]] | ||
| + | [[Category: Teyra J]] | ||
Current revision
Structure of the MM2 Erbin PDZ variant in complex with a high-affinity peptide
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