7mwy

<table><tr><td colspan='2'>[[7mwy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Droeu Droeu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MWY FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mwy OCA], [https://pdbe.org/7mwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mwy RCSB], [https://www.ebi.ac.uk/pdbsum/7mwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mwy ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that produces the second messenger 2'3'-cGAMP and controls activation of innate immunity in mammalian cells(1-5). Animal genomes typically encode multiple proteins with predicted homology to cGAS(6-10), but the function of these uncharacterized enzymes is unknown. Here we show that cGAS-like receptors (cGLRs) are innate immune sensors capable of recognizing divergent molecular patterns and catalyzing synthesis of distinct nucleotide second messenger signals. Crystal structures of human and insect cGLRs reveal a nucleotidyltransferase signaling core shared with cGAS and a diversified primary ligand-binding surface modified with significant insertions and deletions. We demonstrate that cGLR surface remodeling enables altered ligand specificity and use a forward biochemical screen to identify cGLR1 as a double-stranded RNA sensor in the model organism Drosophila melanogaster. Surprisingly, RNA recognition activates Drosophila cGLR1 to synthesize the novel product cG[3'-5']pA[2'-5']p (3'2'-cGAMP). A crystal structure of Drosophila Stimulator of Interferon Genes (STING) in complex with 3'2'-cGAMP explains selective isomer recognition and we demonstrate that 3'2'-cGAMP induces an enhanced antiviral state in vivo that protects from viral infection. Similar to radiation of Toll-like receptors in pathogen immunity, our results establish cGLRs as a diverse family of metazoan pattern recognition receptors.

 

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== References ==

[[Category: Droeu]]

[[Category: Kranzusch, P J]]

[[Category: Ragucci, A E]]

[[Category: Slavik, K M]]

[[Category: Sting]]