7rxl
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==Fab1488 in complex with the C-terminal alpha-TSR domain of P. falciparum== |
| - | <StructureSection load='7rxl' size='340' side='right'caption='[[7rxl]]' scene=''> | + | <StructureSection load='7rxl' size='340' side='right'caption='[[7rxl]], [[Resolution|resolution]] 1.82Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7rxl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RXL FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rxl OCA], [https://pdbe.org/7rxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rxl RCSB], [https://www.ebi.ac.uk/pdbsum/7rxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rxl ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.823Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rxl OCA], [https://pdbe.org/7rxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rxl RCSB], [https://www.ebi.ac.uk/pdbsum/7rxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rxl ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CSP_PLAF7 CSP_PLAF7] Essential sporozoite protein (PubMed:29554084, PubMed:32150583). In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands (By similarity). In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes (PubMed:29554084, PubMed:32150583). Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes (By similarity).[UniProtKB:P23093]<ref>PMID:29554084</ref> <ref>PMID:32150583</ref> In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.[UniProtKB:P23093] | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Plasmodium falciparum 3D7]] |
| + | [[Category: Oyen D]] | ||
| + | [[Category: Pholcharee T]] | ||
| + | [[Category: Wilson IA]] | ||
Revision as of 07:20, 3 April 2024
Fab1488 in complex with the C-terminal alpha-TSR domain of P. falciparum
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