7shg

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Current revision (07:20, 3 April 2024) (edit) (undo)
 
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<StructureSection load='7shg' size='340' side='right'caption='[[7shg]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='7shg' size='340' side='right'caption='[[7shg]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7shg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SHG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SHG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7shg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermobacillus_composti Thermobacillus composti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SHG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SHG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7shg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7shg OCA], [https://pdbe.org/7shg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7shg RCSB], [https://www.ebi.ac.uk/pdbsum/7shg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7shg ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7shg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7shg OCA], [https://pdbe.org/7shg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7shg RCSB], [https://www.ebi.ac.uk/pdbsum/7shg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7shg ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/L0EJI9_THECK L0EJI9_THECK]
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Bacterial surface polysaccharides are assembled by glycosyltransferase enzymes that typically use sugar nucleotide or polyprenyl-monophosphosugar activated donors. Characterized representatives exist for many monosaccharides but neither the donor nor the corresponding glycosyltransferases have been definitively identified for ribofuranose residues found in some polysaccharides. Klebsiella pneumoniae O-antigen polysaccharides provided prototypes to identify dual-domain ribofuranosyltransferase proteins catalyzing a two-step reaction sequence. Phosphoribosyl-5-phospho-D-ribosyl-alpha-1-diphosphate serves as the donor for a glycan acceptor-specific phosphoribosyl transferase (gPRT), and a more promiscuous phosphoribosyl-phosphatase (PRP) then removes the residual 5'-phosphate. The 2.5-A resolution crystal structure of a dual-domain ribofuranosyltransferase ortholog from Thermobacillus composti revealed a PRP domain that conserves many features of the phosphatase members of the haloacid dehalogenase family, and a gPRT domain that diverges substantially from all previously characterized phosphoribosyl transferases. The gPRT represents a new glycosyltransferase fold conserved in the most abundant ribofuranosyltransferase family.
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The biosynthetic origin of ribofuranose in bacterial polysaccharides.,Kelly SD, Williams DM, Nothof JT, Kim T, Lowary TL, Kimber MS, Whitfield C Nat Chem Biol. 2022 May;18(5):530-537. doi: 10.1038/s41589-022-01006-6. Epub 2022, Apr 7. PMID:35393575<ref>PMID:35393575</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7shg" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kelly, S D]]
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[[Category: Thermobacillus composti]]
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[[Category: Kimber, M S]]
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[[Category: Kelly SD]]
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[[Category: Glycosyltransferase]]
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[[Category: Kimber MS]]
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[[Category: Phosphatase]]
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[[Category: Ribofuranose]]
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[[Category: Transferase]]
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Current revision

Polysaccharide ribofuranosyl transferase from Thermobacillus composti

PDB ID 7shg

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