8epg

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8epg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8epg OCA], [https://pdbe.org/8epg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8epg RCSB], [https://www.ebi.ac.uk/pdbsum/8epg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8epg ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Sequence-selective recognition of DNA duplexes is important for a wide range of applications including regulating gene expression, drug development, and genome editing. Many small molecules can bind DNA duplexes with sequence selectivity. It remains as a challenge how to reliably and conveniently obtain the detailed structural information on DNA-molecule interactions because such information is critically needed for understanding the underlying rules of DNA-molecule interactions. If those rules were understood, we could design molecules to recognize DNA duplexes with a sequence preference and intervene in related biological processes, such as disease treatment. Here, we have demonstrated that DNA crystal engineering is a potential solution. A molecule-binding DNA sequence is engineered to self-assemble into highly ordered DNA crystals. An X-ray crystallographic study of molecule-DNA cocrystals reveals the structural details on how the molecule interacts with the DNA duplex. In this approach, the DNA will serve two functions: (1) being part of the molecule to be studied and (2) forming the crystal lattice. It is conceivable that this method will be a general method for studying drug/peptide-DNA interactions. The resulting DNA crystals may also find use as separation matrices, as hosts for catalysts, and as media for material storage.

Engineering DNA Crystals toward Studying DNA-Guest Molecule Interactions.,Zhang C, Zhao J, Lu B, Seeman NC, Sha R, Noinaj N, Mao C J Am Chem Soc. 2023 Mar 1;145(8):4853-4859. doi: 10.1021/jacs.3c00081. Epub 2023 , Feb 15. PMID:36791277<ref>PMID:36791277</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

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