1hy9
From Proteopedia
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==COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT== | ==COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT== | ||
| - | <StructureSection load='1hy9' size='340' side='right'caption='[[1hy9 | + | <StructureSection load='1hy9' size='340' side='right'caption='[[1hy9]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1hy9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1hy9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HY9 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hy9 OCA], [https://pdbe.org/1hy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hy9 RCSB], [https://www.ebi.ac.uk/pdbsum/1hy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hy9 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hy9 OCA], [https://pdbe.org/1hy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hy9 RCSB], [https://www.ebi.ac.uk/pdbsum/1hy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hy9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/CART_HUMAN CART_HUMAN] Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro.<ref>PMID:9590691</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hy9 ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hy9 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Cocaine and amphetamine regulated transcript (CART) peptide has been shown to be an anorectic peptide that inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. The C-terminal part containing the three disulfide bridges CART(48-89) is the biologically active part of the molecule affecting food intake. The solution structure of the active part of CART has a fold equivalent to other functionally distinct small proteins. CART consists mainly of turns and loops spanned by a compact framework composed by a few small stretches of antiparallel beta-sheet common to cystine knots. | ||
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| - | Solution structure of the satiety factor, CART, reveals new functionality of a well-known fold.,Ludvigsen S, Thim L, Blom AM, Wulff BS Biochemistry. 2001 Aug 7;40(31):9082-8. PMID:11478874<ref>PMID:11478874</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 1hy9" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Blom | + | [[Category: Blom AM]] |
| - | [[Category: Ludvigsen | + | [[Category: Ludvigsen S]] |
| - | [[Category: Thim | + | [[Category: Thim L]] |
| - | [[Category: Wulff | + | [[Category: Wulff BS]] |
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Revision as of 07:42, 3 April 2024
COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT
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