1i1j

<table><tr><td colspan='2'>[[1i1j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I1J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I1J FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i1j OCA], [https://pdbe.org/1i1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i1j RCSB], [https://www.ebi.ac.uk/pdbsum/1i1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i1j ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/MIA_HUMAN MIA_HUMAN]] Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.

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== Publication Abstract from PubMed ==

Melanoma inhibitory activity (MIA) is a 12-kDa protein that is secreted from both chondrocytes and malignant melanoma cells. MIA has been reported to have effects on cell growth and adhesion, and it may play a role in melanoma metastasis and cartilage development. We report the 1.4-A crystal structure of human MIA, which consists of an Src homology 3 (SH3)-like domain with N- and C-terminal extensions of about 20 aa. each. The N- and C-terminal extensions add additional structural elements to the SH3 domain, forming a previously undescribed fold. MIA is a representative of a recently identified family of proteins and is the first structure of a secreted protein with an SH3 subdomain. The structure also suggests a likely protein interaction site and suggests that, unlike conventional SH3 domains, MIA does not recognize polyproline helices.

Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins.,Lougheed JC, Holton JM, Alber T, Bazan JF, Handel TM Proc Natl Acad Sci U S A. 2001 May 8;98(10):5515-20. Epub 2001 May 1. PMID:11331761<ref>PMID:11331761</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1i1j" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Human]]

[[Category: Alber, T]]

[[Category: Bazan, J F]]

[[Category: Handel, T M]]

[[Category: Holton, J M]]

[[Category: Lougheed, J C]]

[[Category: Sh3 subdomain]]