1rhw
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1rhw.jpg|left|200px]] | [[Image:1rhw.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1rhw", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | + | {{STRUCTURE_1rhw| PDB=1rhw | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''The solution structure of the pH-induced monomer of dynein light chain LC8 from Drosophila''' | '''The solution structure of the pH-induced monomer of dynein light chain LC8 from Drosophila''' | ||
| Line 30: | Line 27: | ||
[[Category: Makokha, M.]] | [[Category: Makokha, M.]] | ||
[[Category: Montelione, G.]] | [[Category: Montelione, G.]] | ||
| - | [[Category: | + | [[Category: Dimer interface]] |
| - | [[Category: | + | [[Category: Domain swapped]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:30:59 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 04:31, 3 May 2008
The solution structure of the pH-induced monomer of dynein light chain LC8 from Drosophila
Overview
The structure of Drosophila LC8 pH-induced monomer has been determined by NMR spectroscopy using the program AutoStructure. The structure at pH 3 and 30 degrees C is similar to the individual subunits of mammalian LC8 dimer with the exception that a beta strand, which crosses between monomers to form an intersubunit beta-sheet in the dimer, is a flexible loop with turnlike conformations in the monomer. Increased flexibility in the interface region relative to the rest of the protein is confirmed by dynamic measurements based on (15)N relaxation. Comparison of the monomer and dimer structures indicates that LC8 is not a domain swapped dimer.
About this Structure
1RHW is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
The solution structure of the pH-induced monomer of dynein light-chain LC8 from Drosophila., Makokha M, Huang YJ, Montelione G, Edison AS, Barbar E, Protein Sci. 2004 Mar;13(3):727-34. Epub 2004 Feb 6. PMID:14767079 Page seeded by OCA on Sat May 3 07:30:59 2008
