1ri2

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[[Image:1ri2.gif|left|200px]]
[[Image:1ri2.gif|left|200px]]
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{{Structure
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|SITE=
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|LIGAND= <scene name='pdbligand=GTG:7-METHYL-GUANOSINE-5&#39;-TRIPHOSPHATE-5&#39;-GUANOSINE'>GTG</scene>
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|GENE= ECU10_0380 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6035 Encephalitozoon cuniculi])
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|DOMAIN=
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{{STRUCTURE_1ri2| PDB=1ri2 | SCENE= }}
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|RELATEDENTRY=[[1ri1|1RI1]], [[1ri3|1RI3]], [[1ri4|1RI4]], [[1ri5|1RI5]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ri2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ri2 OCA], [http://www.ebi.ac.uk/pdbsum/1ri2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ri2 RCSB]</span>
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'''Structure and mechanism of mRNA cap (guanine N-7) methyltransferase'''
'''Structure and mechanism of mRNA cap (guanine N-7) methyltransferase'''
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[[Category: Shen, V.]]
[[Category: Shen, V.]]
[[Category: Shuman, S.]]
[[Category: Shuman, S.]]
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[[Category: cap]]
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[[Category: Cap]]
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[[Category: m7g]]
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[[Category: M7g]]
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[[Category: messenger rna cap]]
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[[Category: Messenger rna cap]]
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[[Category: methyltransferase]]
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[[Category: Methyltransferase]]
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[[Category: rna]]
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[[Category: Rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:31:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:28:27 2008''
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Revision as of 04:31, 3 May 2008

Image:1ri2.gif

Template:STRUCTURE 1ri2

Structure and mechanism of mRNA cap (guanine N-7) methyltransferase


Overview

A suite of crystal structures is reported for a cellular mRNA cap (guanine-N7) methyltransferase in complex with AdoMet, AdoHcy, and the cap guanylate. Superposition of ligand complexes suggests an in-line mechanism of methyl transfer, albeit without direct contacts between the enzyme and either the N7 atom of guanine (the attacking nucleophile), the methyl carbon of AdoMet, or the sulfur of AdoMet/AdoHcy (the leaving group). The structures indicate that catalysis of cap N7 methylation is accomplished by optimizing proximity and orientation of the substrates, assisted by a favorable electrostatic environment. The enzyme-ligand structures, together with new mutational data, fully account for the biochemical specificity of the cap guanine-N7 methylation reaction, an essential and defining step of eukaryotic mRNA synthesis.

About this Structure

1RI2 is a Single protein structure of sequence from Encephalitozoon cuniculi. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of mRNA cap (guanine-N7) methyltransferase., Fabrega C, Hausmann S, Shen V, Shuman S, Lima CD, Mol Cell. 2004 Jan 16;13(1):77-89. PMID:14731396 Page seeded by OCA on Sat May 3 07:31:27 2008

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