1k19

<StructureSection load='1k19' size='340' side='right'caption='[[1k19]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[1k19]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cabbage_moth Cabbage moth]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K19 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k19 OCA], [https://pdbe.org/1k19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k19 RCSB], [https://www.ebi.ac.uk/pdbsum/1k19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k19 ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Chemosensory proteins (CSPs) are believed to be involved in chemical communication and perception. A number of such proteins, of molecular mass approximately 13 kDa, have been isolated from different sensory organs of a wide range of insect species. Several CSPs have been identified in the antennae and proboscis of the moth Mamestra brassicae. CSPMbraA6, a 112-amino-acid antennal protein, has been expressed in a soluble form in large quantities in the Escherichi coli periplasm. NMR structure determination of CSPMbraA6 has been performed with 1H- and 15N-labelled samples. The calculated structures present an average root mean square deviation about the mean structure of 0.63 A for backbone atoms and 1.27 A for all non-hydrogen atoms except the 12 N-terminal residues. The protein is well folded from residue 12 to residue 110, and consists of a non-bundle alpha-helical structure with six helices connected by alpha alpha loops. It has a globular shape, with overall dimensions of 32 A x 28 A x 24 A. A channel is visible in the hydrophobic core, with dimensions of 3 A x 9 A x 21 A. In some of the 20 solution structures calculated, this channel is closed either by Trp-94 at one end or by Tyr-26 at the other end; in some other solutions, this channel is closed at both ends. Binding experiments with 12-bromododecanol indicate that the CSPMbraA6 structure is modified upon ligand binding.

Solution structure of a chemosensory protein from the moth Mamestra brassicae.,Mosbah A, Campanacci V, Lartigue A, Tegoni M, Cambillau C, Darbon H Biochem J. 2003 Jan 1;369(Pt 1):39-44. PMID:12217077<ref>PMID:12217077</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Cabbage moth]]

[[Category: Cambillau, C]]

[[Category: Campanacci, V]]

[[Category: Darbon, H]]

[[Category: Lartigue, A]]

[[Category: Mosbah, A]]

[[Category: Tegoni, M]]

[[Category: Pheromone]]