1rif

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[[Image:1rif.jpg|left|200px]]
[[Image:1rif.jpg|left|200px]]
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{{Structure
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|PDB= 1rif |SIZE=350|CAPTION= <scene name='initialview01'>1rif</scene>, resolution 2.&Aring;
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The line below this paragraph, containing "STRUCTURE_1rif", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=AU:GOLD+ION'>AU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= UVSW, DAR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 Enterobacteria phage T4])
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|DOMAIN=
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{{STRUCTURE_1rif| PDB=1rif | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rif OCA], [http://www.ebi.ac.uk/pdbsum/1rif PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rif RCSB]</span>
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'''Crystal structure of the UvsW helicase from Bacteriophage T4'''
'''Crystal structure of the UvsW helicase from Bacteriophage T4'''
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[[Category: Sickmier, E A.]]
[[Category: Sickmier, E A.]]
[[Category: White, S W.]]
[[Category: White, S W.]]
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[[Category: bacteriophage]]
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[[Category: Bacteriophage]]
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[[Category: helicase]]
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[[Category: Helicase]]
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[[Category: recg]]
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[[Category: Recg]]
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[[Category: sf2]]
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[[Category: Sf2]]
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[[Category: t4]]
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[[Category: T4]]
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[[Category: uvsw]]
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[[Category: Uvsw]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:32:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:28:35 2008''
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Revision as of 04:32, 3 May 2008

Image:1rif.jpg

Template:STRUCTURE 1rif

Crystal structure of the UvsW helicase from Bacteriophage T4


Overview

In bacteriophage T4, the WXY system repairs DNA damage by a process that involves homologous recombination. This system comprises three proteins, the RecA-like recombination protein UvsX, a recombination mediator protein UvsY, and a helicase UvsW. Here we report the 2.0 A resolution crystal structure of the N-terminal two domains of the UvsW helicase (UvsWNF; residues 1-282). The structure reveals a typical helicase RecA-like domain linked to a small N-terminal alpha/beta domain that likely binds the nucleic acid substrate. The missing C-terminal portion of UvsW almost certainly corresponds to the second RecA-like domain typically found in monomeric helicases. The putative substrate binding domain is unique within the known helicase structures, and it resembles the novel "double-wing" DNA binding domain from the phage T4 MotA transcription factor that mediates the expression of T4 middle genes. The functional implications of this homology for the role of UvsW in T4 DNA metabolism are discussed.

About this Structure

1RIF is a Single protein structure of sequence from Enterobacteria phage t4. Full crystallographic information is available from OCA.

Reference

The crystal structure of the UvsW helicase from bacteriophage T4., Sickmier EA, Kreuzer KN, White SW, Structure. 2004 Apr;12(4):583-92. PMID:15062081 Page seeded by OCA on Sat May 3 07:32:06 2008

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