1koe

<table><tr><td colspan='2'>[[1koe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KOE FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1koe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1koe OCA], [https://pdbe.org/1koe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1koe RCSB], [https://www.ebi.ac.uk/pdbsum/1koe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1koe ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/COIA1_MOUSE COIA1_MOUSE]] Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.

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== Publication Abstract from PubMed ==

A number of extracellular proteins contain cryptic inhibitors of angiogenesis. Endostatin is a 20 kDa C-terminal proteolytic fragment of collagen XVIII that potently inhibits endothelial cell proliferation and angiogenesis. Therapy of experimental cancer with endostatin leads to tumour dormancy and does not induce resistance. We have expressed recombinant mouse endostatin and determined its crystal structure at 1.5 A resolution. The structure reveals a compact fold distantly related to the C-type lectin carbohydrate recognition domain and the hyaluronan-binding Link module. The high affinity of endostatin for heparin is explained by the presence of an extensive basic patch formed by 11 arginine residues. Endostatin may inhibit angiogenesis by binding to the heparan sulphate proteoglycans involved in growth factor signalling.

Crystal structure of the angiogenesis inhibitor endostatin at 1.5 A resolution.,Hohenester E, Sasaki T, Olsen BR, Timpl R EMBO J. 1998 Mar 16;17(6):1656-64. PMID:9501087<ref>PMID:9501087</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Lk3 transgenic mice]]

[[Category: Hohenester, E]]

[[Category: Olsen, B R]]

[[Category: Sasaki, T]]

[[Category: Timpl, R]]

[[Category: Non-collageneous domain]]