1ktj

<table><tr><td colspan='2'>[[1ktj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Derpt Derpt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KTJ FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ktj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ktj OCA], [https://pdbe.org/1ktj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ktj RCSB], [https://www.ebi.ac.uk/pdbsum/1ktj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ktj ProSAT]</span></td></tr>

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

The crystal structure of the common house mite (Dermatophagoides sp.) Der p 2 allergen was solved at 2.15 A resolution using the MAD phasing technique, and refined to an R-factor of 0.209. The refined atomic model, which reveals an immunoglobulin-like tertiary fold, differs in important ways from the previously described NMR structure, because the two beta-sheets are significantly further apart and create an internal cavity, which is occupied by a hydrophobic ligand. This interaction is structurally reminiscent of the binding of a prenyl group by a regulatory protein, the Rho guanine nucleotide exchange inhibitor. The crystal structure suggests that binding of non-polar molecules may be essential to the physiological function of the Der p 2 protein.

The crystal structure of a major dust mite allergen Der p 2, and its biological implications.,Derewenda U, Li J, Derewenda Z, Dauter Z, Mueller GA, Rule GS, Benjamin DC J Mol Biol. 2002 Apr 19;318(1):189-97. PMID:12054778<ref>PMID:12054778</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

</div>

<div class="pdbe-citations 1ktj" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Derpt]]

[[Category: Benjamin, D C]]

[[Category: Dauter, Z]]

[[Category: Derewenda, U]]

[[Category: Derewenda, Z]]

[[Category: Li, J]]

[[Category: Mueller, G A]]

[[Category: Rule, G S]]

[[Category: Immunoglobulin fold]]