Glucagon-Like Peptide 1 Receptor or GLP1-R uses the glucagon-like peptide to signal the body to secrete insulin and inhibit glucagon secretion. When glucose levels in the blood rise (usually after consuming food), GLP-1R activates, creating a signaling cascade to signal cAMP. After the signaling cascade, the final result is the secretion of insulin to the rest of the body. Discovered in 1990s while trying to understand the mechanism of GLP-1 action. The structure was determined using cryogenic electron microscopy.

Function

Disease

^[1]

Diabetes and Obesity

Overview on Diabetes[1]

Ligand and Receptor Interactions

Hormone Interactions

Drug Interactions

Relevance

The long term effects of GLP-1R related drugs are unknown. There have been some hints toward thyroid cancers but this was only shown in mice during trial periods.