User:Camille Gaudet/Sandbox 1

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<scene name='10/1037488/Gip-y1-intrxn-still/1'>Crucial Y1 Interaction</scene>
<scene name='10/1037488/Gip-y1-intrxn-still/1'>Crucial Y1 Interaction</scene>
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[[Image:GIP-Y1-Interaction.png|400 px|right|thumb|Figure 2. Crucial interaction between Tyr1 of GIP and corresponding GIPR residues.]]
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[[Image:GIP-Y1-Interaction.png|400 px|right|thumb|Figure 1. I will delete this but keeping for picture formatting guide.]]
== Associated Diseases ==
== Associated Diseases ==
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<scene name='10/1037488/Tirz-bound/2'>Bound Tirzepatide</scene>
<scene name='10/1037488/Tirz-bound/2'>Bound Tirzepatide</scene>
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[[Image:sequencealignment.png|400 px|right|thumb|Figure 2. Sequence alignment of GLP-1 (red), GIP (pink), and Tirzepatide (blue). Residues highlighted in blue are unique to trizepatide, and residues highlighted in black are found in the sequence of all three of the incretin polypeptides.]]

Revision as of 13:45, 9 April 2024

Glucose-dependent Insulinotropic Polypeptide Receptor

Glucose-dependent Insulinotropic Polypeptide, 7RA3

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References

[1]

  1. Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW. Structural determinants of dual incretin receptor agonism by tirzepatide. Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2116506119. PMID:35333651 doi:10.1073/pnas.2116506119

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