1rji
From Proteopedia
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[[Image:1rji.gif|left|200px]] | [[Image:1rji.gif|left|200px]] | ||
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'''Solution Structure of BmKX, a novel potassium channel blocker from the Chinese Scorpion Buthus martensi Karsch''' | '''Solution Structure of BmKX, a novel potassium channel blocker from the Chinese Scorpion Buthus martensi Karsch''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1RJI is a [[Single protein]] structure | + | 1RJI is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RJI OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Xu, Y.]] | [[Category: Xu, Y.]] | ||
[[Category: 3-10 helix]] | [[Category: 3-10 helix]] | ||
| - | [[Category: | + | [[Category: Beta sheet]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:34:21 2008'' | |
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Revision as of 04:34, 3 May 2008
Solution Structure of BmKX, a novel potassium channel blocker from the Chinese Scorpion Buthus martensi Karsch
Overview
Scorpion venom is a rich source of bioactive peptides. From the venom of Chinese scorpion Buthus martensi Karsch (BmK), a novel short chain peptide BmKX of 31-amino acid residues was purified, and its amino acid sequence and gene structure were determined. The gene of BmKX was composed of two exons interrupted by an 86-bp intron at the codon-7 upstream of the mature peptide. Although its gene structure is similar to those of other known scorpion toxins, its amino acid sequence, especially the cysteine framework, is different from those of all other known subfamilies of short-chain scorpion toxins. The solution structure of BmKX, determined with two-dimensional NMR spectroscopy, shows that BmKX also forms a typical cysteine-stabilized alpha/beta scaffold adopted by most short-chain scorpion toxins, consisting of a short 3(10)-helix and a two-stranded antiparallel beta-sheet, and the short N-terminal segment forms a pseudo-strand of the beta-sheet. However, the orientation between the helix and the beta-sheet is significantly different from the others, which might be the reason for its unique but still unclear physiological function.
About this Structure
1RJI is a Single protein structure. Full crystallographic information is available from OCA.
Reference
A novel short-chain peptide BmKX from the Chinese scorpion Buthus martensi Karsch, sequencing, gene cloning and structure determination., Wang CG, Cai Z, Lu W, Wu J, Xu Y, Shi Y, Chi CW, Toxicon. 2005 Mar 1;45(3):309-19. Epub 2005 Jan 20. PMID:15683869 Page seeded by OCA on Sat May 3 07:34:21 2008
Categories: Single protein | Cai, Z. | Chi, C W. | Shi, Y. | Wang, C G. | Wu, J. | Xu, Y. | 3-10 helix | Beta sheet
