1rjt
From Proteopedia
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[[Image:1rjt.jpg|left|200px]] | [[Image:1rjt.jpg|left|200px]] | ||
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'''NMR Structure of CXC Chemokine CXCL11/ITAC''' | '''NMR Structure of CXC Chemokine CXCL11/ITAC''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1RJT is a [[Single protein]] structure | + | 1RJT is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RJT OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Clark-Lewis, I.]] | [[Category: Clark-Lewis, I.]] | ||
[[Category: Sykes, B D.]] | [[Category: Sykes, B D.]] | ||
| - | [[Category: | + | [[Category: Chemokine]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:35:09 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 04:35, 3 May 2008
NMR Structure of CXC Chemokine CXCL11/ITAC
Overview
CXCL11 (ITAC) is one of three chemokines known to bind the receptor CXCR3, the two others being CXCL9 (Mig) and CXCL10 (IP-10). CXCL11 differs from the other CXCR3 ligands in both the strength and the particularities of its receptor interactions: It has a higher affinity, is a stronger agonist, and behaves differently when critical N-terminal residues are deleted. The structure of CXCL11 was determined using solution NMR to allow comparison with that of CXCL10 and help elucidate the source of the differences. CXCL11 takes on the canonical chemokine fold but exhibits greater conformational flexibility than has been observed for related chemokines under the same sample conditions. Unlike related chemokines such as IP-10 and IL-8, ITAC does not appear to form dimers at millimolar concentrations. The origin for this behavior can be found in the solution structure, which indicates a beta-bulge in beta-strand 1 that distorts the dimerization interface used by other CXC chemokines.
About this Structure
1RJT is a Single protein structure. Full crystallographic information is available from OCA.
Reference
NMR structure of CXCR3 binding chemokine CXCL11 (ITAC)., Booth V, Clark-Lewis I, Sykes BD, Protein Sci. 2004 Aug;13(8):2022-8. PMID:15273303 Page seeded by OCA on Sat May 3 07:35:09 2008
