1rju
From Proteopedia
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[[Image:1rju.gif|left|200px]] | [[Image:1rju.gif|left|200px]] | ||
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'''Crystal structure of a truncated form of yeast copper thionein''' | '''Crystal structure of a truncated form of yeast copper thionein''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1RJU is a [[Single protein]] structure | + | 1RJU is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RJU OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Mangani, S.]] | [[Category: Mangani, S.]] | ||
[[Category: Weser, U.]] | [[Category: Weser, U.]] | ||
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Revision as of 04:35, 3 May 2008
Crystal structure of a truncated form of yeast copper thionein
Overview
We report here the crystal structure of yeast copper thionein (Cu-MT), determined at 1.44-A resolution. The Cu-MT structure shows the largest known oligonuclear Cu(I) thiolate cluster in biology, consisting of six trigonally and two digonally coordinated Cu(I) ions. This is at variance with the results from previous spectroscopic determinations, which were performed on MT samples containing seven rather than eight metal ions. The protein backbone has a random coil structure with the loops enfolding the copper cluster, which is located in a cleft where it is bound to 10 cysteine residues. The protein structure is somewhat different from that of Ag(7)-MT and similar, but not identical, to that of Cu(7)-MT. Besides the different structure of the metal cluster, the main differences lie in the cysteine topology and in the conformation of some portions of the backbone. The present structure suggests that Cu-MT, in addition to its role as a safe depository for copper ions in the cell, may play an active role in the delivery of copper to metal-free chaperones.
About this Structure
1RJU is a Single protein structure. Full crystallographic information is available from OCA.
Reference
The crystal structure of yeast copper thionein: the solution of a long-lasting enigma., Calderone V, Dolderer B, Hartmann HJ, Echner H, Luchinat C, Del Bianco C, Mangani S, Weser U, Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):51-6. Epub 2004 Dec 21. PMID:15613489 Page seeded by OCA on Sat May 3 07:35:10 2008
