8ong

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m (Protected "8ong" [edit=sysop:move=sysop])
Current revision (08:01, 10 April 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8ong is ON HOLD
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==Structure of the endothelial monocyte activating polypeptide II (EMAP II) in solution==
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<StructureSection load='8ong' size='340' side='right'caption='[[8ong]]' scene=''>
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Authors: Lozhko, D., Kolomiiets, L., Kornelyuk, A.I., Zhukov, I.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8ong]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ONG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ONG FirstGlance]. <br>
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Description: Structure of the endothelial monocyte activating polypeptide II (EMAP II) in solution
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Hybrid , Solution NMR , X-ray solution scattering</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ong FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ong OCA], [https://pdbe.org/8ong PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ong RCSB], [https://www.ebi.ac.uk/pdbsum/8ong PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ong ProSAT]</span></td></tr>
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[[Category: Zhukov, I]]
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</table>
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[[Category: Kornelyuk, A.I]]
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== Disease ==
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[[Category: Lozhko, D]]
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[https://www.uniprot.org/uniprot/AIMP1_HUMAN AIMP1_HUMAN] Defects in AIMP1 are the cause of leukodystrophy hypomyelinating type 3 (HLD3) [MIM:[https://omim.org/entry/260600 260600]. A severe autosomal recessive hypomyelinating leukodystrophy characterized by early infantile onset of global developmental delay, lack of development, lack of speech acquisition, and peripheral spasticity associated with decreased myelination in the central nervous system.<ref>PMID:21092922</ref>
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[[Category: Kolomiiets, L]]
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== Function ==
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[https://www.uniprot.org/uniprot/AIMP1_HUMAN AIMP1_HUMAN] Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.<ref>PMID:10358004</ref> <ref>PMID:11306575</ref> <ref>PMID:12237313</ref> <ref>PMID:11818442</ref> <ref>PMID:19362550</ref> <ref>PMID:11157763</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Kolomiiets L]]
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[[Category: Kornelyuk AI]]
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[[Category: Lozhko D]]
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[[Category: Zhukov I]]

Current revision

Structure of the endothelial monocyte activating polypeptide II (EMAP II) in solution

PDB ID 8ong

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