1lud
From Proteopedia
(Difference between revisions)
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==SOLUTION STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETHOPRIM AND NADPH, 24 STRUCTURES== | ==SOLUTION STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETHOPRIM AND NADPH, 24 STRUCTURES== | ||
| - | <StructureSection load='1lud' size='340' side='right'caption='[[1lud | + | <StructureSection load='1lud' size='340' side='right'caption='[[1lud]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1lud]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1lud]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LUD FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=TRR:2,4-DIAMINO-5-(3,4,5-TRIMETHOXY-BENZYL)-PYRIMIDIN-1-IUM'>TRR</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=TRR:2,4-DIAMINO-5-(3,4,5-TRIMETHOXY-BENZYL)-PYRIMIDIN-1-IUM'>TRR</scene></td></tr> | |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lud OCA], [https://pdbe.org/1lud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lud RCSB], [https://www.ebi.ac.uk/pdbsum/1lud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lud ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lud OCA], [https://pdbe.org/1lud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lud RCSB], [https://www.ebi.ac.uk/pdbsum/1lud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lud ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/DYR_LACCA DYR_LACCA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Lacticaseibacillus casei]] |
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Birdsall | + | [[Category: Birdsall B]] |
| - | [[Category: Feeney | + | [[Category: Feeney J]] |
| - | [[Category: Kelly | + | [[Category: Kelly G]] |
| - | [[Category: Polshakov | + | [[Category: Polshakov VI]] |
| - | [[Category: Smirnov | + | [[Category: Smirnov EG]] |
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Current revision
SOLUTION STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETHOPRIM AND NADPH, 24 STRUCTURES
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