1m4r

<table><tr><td colspan='2'>[[1m4r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M4R FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4r OCA], [https://pdbe.org/1m4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m4r RCSB], [https://www.ebi.ac.uk/pdbsum/1m4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m4r ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/IL22_HUMAN IL22_HUMAN]] Cytokine that contributes to the inflammatory response in vivo.

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== Publication Abstract from PubMed ==

Interleukin-22 (IL-10-related T cell-derived inducible factor/IL-TIF/IL-22) is a novel cytokine belonging to the IL-10 family. Recombinant human IL-22 (hIL-22) was found to activate the signal transducers and activators of transcription factors 1 and 3 as well as acute phase reactants in several hepatoma cell lines, suggesting its involvement in the inflammatory response. The crystallographic structure of recombinant hIL-22 has been solved at 2.0 A resolution using the SIRAS method. Contrary to IL-10, the hIL-22 dimer does not present an interpenetration of the secondary-structure elements belonging to the two distinct polypeptide chains but results from interface interactions between monomers. Structural differences between these two cytokines, revealed by the crystallographic studies, clearly indicate that, while a homodimer of IL-10 is required for signaling, hIL-22 most probably interacts with its receptor as a monomer.

Crystal structure of recombinant human interleukin-22.,Nagem RA, Colau D, Dumoutier L, Renauld JC, Ogata C, Polikarpov I Structure. 2002 Aug;10(8):1051-62. PMID:12176383<ref>PMID:12176383</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1m4r" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Human]]

[[Category: Colau, D]]

[[Category: Dumoutier, L]]

[[Category: Nagem, R A.P]]

[[Category: Ogata, C]]

[[Category: Polikarpov, I]]

[[Category: Renauld, J C]]

[[Category: Interferon-gamma]]