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1n4y
From Proteopedia
(Difference between revisions)
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==REFINED STRUCTURE OF KISTRIN== | ==REFINED STRUCTURE OF KISTRIN== | ||
| - | <StructureSection load='1n4y' size='340' side='right'caption='[[1n4y | + | <StructureSection load='1n4y' size='340' side='right'caption='[[1n4y]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1n4y]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1n4y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1kst 1kst]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N4Y FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4y OCA], [https://pdbe.org/1n4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n4y RCSB], [https://www.ebi.ac.uk/pdbsum/1n4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n4y ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/VM2RH_CALRH VM2RH_CALRH] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n4y ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n4y ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | The structure of kistrin, which is a member of a homologous family of glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein inhibitors of platelet aggregation, has been determined by two-dimensional nuclear magnetic resonance (NMR) spectroscopy. The 68-residue protein consists of a series of tightly packed loops held together by six disulfide bonds and has almost no regular secondary structure. Kistrin has an Arg-Gly-Asp (RGD) adhesion site recognition sequence important for binding to GP IIb-IIIa that is located at the apex of a long loop across the surface of the protein. | ||
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| - | Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist.,Adler M, Lazarus RA, Dennis MS, Wagner G Science. 1991 Jul 26;253(5018):445-8. PMID:1862345<ref>PMID:1862345</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 1n4y" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[Disintegrin|Disintegrin]] | *[[Disintegrin|Disintegrin]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Calloselasma rhodostoma]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Dennis | + | [[Category: Dennis MS]] |
| - | [[Category: Krane | + | [[Category: Krane J]] |
| - | [[Category: Krezel | + | [[Category: Krezel AM]] |
| - | [[Category: Lazarus | + | [[Category: Lazarus RA]] |
| - | [[Category: Wagner | + | [[Category: Wagner G]] |
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Current revision
REFINED STRUCTURE OF KISTRIN
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