1rlg

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[[Image:1rlg.gif|left|200px]]
[[Image:1rlg.gif|left|200px]]
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{{Structure
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|PDB= 1rlg |SIZE=350|CAPTION= <scene name='initialview01'>1rlg</scene>, resolution 2.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1rlg", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=5BU:5-BROMO-URIDINE-5&#39;-MONOPHOSPHATE'>5BU</scene>, <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= RPL7AE, AF0764 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2234 Archaeoglobus fulgidus])
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|DOMAIN=
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{{STRUCTURE_1rlg| PDB=1rlg | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rlg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rlg OCA], [http://www.ebi.ac.uk/pdbsum/1rlg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rlg RCSB]</span>
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'''Molecular basis of Box C/D RNA-protein interaction: co-crystal structure of the Archaeal sRNP intiation complex'''
'''Molecular basis of Box C/D RNA-protein interaction: co-crystal structure of the Archaeal sRNP intiation complex'''
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[[Category: Moore, T.]]
[[Category: Moore, T.]]
[[Category: Zhang, Y.]]
[[Category: Zhang, Y.]]
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[[Category: protein-rna]]
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[[Category: Protein-rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:38:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:29:49 2008''
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Revision as of 04:38, 3 May 2008

Image:1rlg.gif

Template:STRUCTURE 1rlg

Molecular basis of Box C/D RNA-protein interaction: co-crystal structure of the Archaeal sRNP intiation complex


Overview

We have determined and refined a crystal structure of the initial assembly complex of archaeal box C/D sRNPs comprising the Archaeoglobus fulgidus (AF) L7Ae protein and a box C/D RNA. The box C/D RNA forms a classical kink-turn (K-turn) structure and the resulting protein-RNA complex serves as a distinct platform for recruitment of the fibrillarin-Nop5p complex. The cocrystal structure confirms previously proposed secondary structure of the box C/D RNA that includes a protruded U, a UU mismatch, and two sheared tandem GA base pairs. Detailed structural comparisons of the AF L7Ae-box C/D RNA complex with previously determined crystal structures of L7Ae homologs in complex with functionally distinct K-turn RNAs revealed a set of remarkably conserved principles in protein-RNA interactions. These analyses provide a structural basis for interpreting the functional roles of the box C/D sequences in directing specific assembly of box C/D sRNPs.

About this Structure

1RLG is a Single protein structure of sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.

Reference

Molecular basis of box C/D RNA-protein interactions; cocrystal structure of archaeal L7Ae and a box C/D RNA., Moore T, Zhang Y, Fenley MO, Li H, Structure. 2004 May;12(5):807-18. PMID:15130473 Page seeded by OCA on Sat May 3 07:38:34 2008

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